Abstract Paper
| Title | : Novel Tc-99m labeled EDTA derivative with improved renal imaging efficiency |
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| Author(s) | : T. Anbalagan, R. Sreeja, K. Eswaramoorthi, A. Jeya Rajendra |
| Article Information | : Volume 3 - Issue 1 (June-2019) , pp 18-24 |
| Affiliation(s) | : Loyola College |
Abstract :
Renal imaging is a well-established nuclear medical investigation. Current renal imaging agents, dimercaptosuccinic acid, mercaptoacetyltriglycine, ethylenecysteine, diethylenetriamine pentaaceticacid and gluceptate have few drawbacks. Thus, there is a need for continuous research in designing and evaluating potentially superior renal imaging agents. Ethylenediamine-N,N-bis (disodiumacetato)-N1-(2-hydroxyethylacetato) -N1-(acetic acid) (EDHEAA), a derivative of a powerful chelating agent, EDTA was synthesized, characterized and radiolabeled with 99mTc by stannous chloride reduction method with a radiochemical purity of 94.08±4.82 % at a pH range of 6.0-7.0. The ratio of EDHEAA, ascorbic acid and SnCl2.2H2O was optimized as 2.5 : 2.5: 0.5 respectively by ascending paper chromatographic analysis and was stable up to 6 h at room temperature and showed hydrophilic nature. Biodistribution of the labeled 99mTc-EDHEAA complex and the commercially available renal imaging agents (99mTc-DTPA and 99mTc-EC) in Wistar rats were studied and compared based on region of interest method. The labeled complex showed substantial retention in left and right kidneys at 20 min post injection and had rapid clearance in urinary bladder. Invitro stability in serum proteins was found to be stable up to 6 h.
| Keywords | : Technetium-99m (Tc-99m), Radiopharmaceuticals, Radiochemical purity, Radiolabeling, Biodistribution, Renal imaging |
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| Document Type | : Research Paper |
| Publication date | : July 17, 2019 |